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Types of fillers

HYALURONIC ACID Fillderma Fillers

Fillderma Fillers

Fillderma ® Repair Revitalizing
This is a transparent, biodegradable, non-animal and non-cross-linked hyaluronic acid gel. It is rapidly absorbed into the skin to replenish the HA lost due to ageing. With its hygroscopic properties, Fillderma Repair ® moisturises the skin and restores its elasticity, firmness, and beauty. Treatments take between 10 and 15 minutes and are repeated regularly at monthly intervals for four consecutive months.
Fillderma ® Repair Revitalizing
It is a high-viscosity, clear, biodegradable HA gel of non-animal origin prepared through a cross-linking process. This process creates a longer lasting gel and is especially suitable for deeper and more pronounced lines and wrinkles, such as the nasolabial folds and the corners of the mouth. It is also used to fill in the superficial imperfections in the dermis, such as fine lines, forehead wrinkles, crow’s feet, peri-orbital lines, and expression lines.

Fillderma ® Repair Revitalizing
The delicate and unique properties of the lips require a specially formulated filler to ensure good results after being injected. Filliderma Lips ® was specifically created for lip augmentation and definition. The result of this design is a product which is easy to inject, highly manageable after the injection, and which causes very little inflammation.

Advantages of Filliderma Fillers

HA is a polysaccharide that can be found naturally in the skin and in other tissue, and it is a key component of the extra-cellular matrix. It helps retain moisture and contributes to the elastic properties of the skin.

As there are many HA fillers in the market, one may wonder, why are Filliderma Fillers ® different? The answer is in our unique formula and in the patented thixotropic cross-linking technology, which makes it possible for a highly viscous gel to be injected through a fine gauge needle easily, without causing degradation to the modified HA particles. Thixotropic fluids can, under pressure (such as the force used when injecting it), increase the flow rate and, later on, return to their original more viscous state once the (injection) pressure has stopped. A special cross-linking process has been designed to boost the effectiveness of the cross-linked HA chains in the gel. The bonds between the different HA polymer chains are stimulated, while the ineffective oscillating bonds between portions of the same chain are minimised. This results in a gel that offers the maximum benefit in terms of mechanic properties and durability, with a minimum amount of BDDE.

The cross-linked HA together with the size of the gel particles are synchronised to produce a gel which flows easily through a fine gauge needle but is under less stress after the intradermal injection, providing elastic properties which give the injected skin a smooth feeling. The osmolarity and pH of the gel are balanced to make it compatible with skin fluids, without accumulating or releasing water. This minimises problems with excess product. As the filling is slowly broken down over time, the cross-linked chains will break, which will enable a slow expansion of the gel particles, thus compensating the natural loss in dermal filling volume, keeping the desired level. The cross-linking degree can also be selected in order to provide the desired durability level in the skin. By optimising all these properties, a dermal filler with a superior performance is obtained, resulting in great patient satisfaction.

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Biphasic and monophasic fillers

In general, HA dermal fillers are classified into two categories: biphasic or monophasic.

Biphasic HA products are formed by stabilised HA gel particles suspended in a not stabilised HA fluid. In contrast, monophasic HA products such as Fillderma ®, are manufactured with stabilised non-particulate HA gel only. This approach doubles the benefits. In the first place, the biphasic and monophasic HA break downs are different: In the biphasic product, the liquid and gel phases behave differently. The HA undergoes a fast initial degradation of the not stabilised HA carrier fluid, and a slower degradation of the stabilised HA gel. To offset this effect, the physician will need to make corrections in order to compensate the fast initial degradation. In contrast, single-phase HA degrades in a simple and consistent way, making it possible for the physician to correct it until reaching the desired look, eliminating the task of having to predict the outcome. In addition, single-phase HA keeps its cohesive properties when water is added (it stays together as a drop of gel) while biphasic products are more dispersed and they separate to form visible micro-particles.

This explains why some biphasic HA patients experience an initial volume loss while this does not occur to selected patients treated with monphasic HA. Secondly, the syringe is filled with fine and soft gel particles which are grouped together. This uniform composition results in the desired quality in the results: softness, smoothness, and accurate filling.

Syringe design

We have taken great care to ensure the Fillderma Fillers ® range is easy to inject. Our syringes have additional wide edges on the extended finger flanges and pistons, which makes them easy to use. This new design offers higher flexibility for the physician to inject. Our special formulation makes it possible for Fillderma ® Ultra, which is highly viscous, to be very easy to inject with fine gauge needles without affecting the gel’s integrity.


The HA used in Fillderma ® dermal fillers is obtained from bacterial biosynthesis, making it safe for humans. With less than 0.025 Ul / mg endotoxin and less than 2 ppm of protein*, it ranks at the highest level of purity.

Fillderma ® dermal fillers are OFL-free products derived from animals, which thus lowers the risk of an immunogenic reaction. The HA used in the Fillderma ® product range integrates naturally into the tissue, keeping the skin healthy and with a natural look. Fillderma ® product range is composed of non-permanent materials, which make it possible for customers to re-evaluate their needs during the treatment as they deem appropriate.

The safety of Fillderma ® fillers is our main concern. The following tests have been carried out:

• Muscle Implementation for 4 weeks

• Acute systemic injection test

• Biocompatibility tests

• Cytotoxicity

• Maximisation and sensitisation in guinea pigs

• Identification: pH, osmolarity, residual BDDE, sterility

• Intracutaneous reactivity

• Mutagenicity

• Proteins

• Reverse mutation analysis

• Interactions with Haemolysis test

• Haemolysis

• Local effect tests after implantation

• Acute toxicity

• Sub-chronic toxicity

• Study on biocompatibility and toxicity after 26 weeks

• Dr. Gabriel Serrano Sanmiguel

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