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Mesotherapy treatment consists of the intradermal injection of small amounts of different substances that vary depending on the problem to be treated: lipolytics, firming, revitalising, anti-wrinkle…

Injections can basically be given in two ways:

  • Manually
  • With assisted injection devices (guns)

Using a gun at the time of injection provides advantages over manual injection that depend on good injection technique:

  • It standardises the procedure and is always injecting
  1. the exact amount (uniform dose)
  2. at the right depths
  3. at the same depth
  • Improves the patient’s comfort (reducing the pain, since it is a quick, brief, and precise shot)


Technique application levels:

  • Facial mesotherapy
  • Body mesotherapy


Advantages of mesotherapy

One of the greatest advantages of mesotherapy treatments is that they are minimally invasive procedures. Neither local nor general anaesthesia is necessary, thus reducing the risks. It is not a painful technique, since the injections are very superficial and deliver very little medication. Additionally, it does not require long recovery times either, nor specific post-traumatic care (except for the use of protective barriers applied after the procedure to avoid the risk of infection).

It is a localised treatment, that is, it is applied specifically to the problem spot. It can be applied to any part of the body except for the breasts.


Cosmetic medicine is a wide spread area within the field of mesotherapy. Its indications and benefits are well-defined in this area. Taking this into account, the most commonly treated pathology, based on being the most requested at the same time are: accumulations of localised fat (inner thighs, back of the thighs, buttocks, hips, abdomen, double chin…) cellulite (Edematous-fibrosclerotic panniculopathy), facial mesotherapy (facial rejuvenation) treatment for sagging skin (breasts, buttocks, abdomen, thighs…), stretch marks, varicules

Risks of mesotherapy

The secondary effects that can appear after mesotherapy treatment are generally localised and related to the injection technique and the active ingredient administered:

Pain at the injection site (closely related to the type of needle used), local oedema and erythema, small hematomas in the injection site, allergies, mechanical lesions (cuts made by the needles due to patients moving or professionals with little experience with this technique, especially when using the coating technique).

These side effects of mesotherapy tend to be mild to moderate and temporary in nature, going away after 2-3 days.

Among the side effects, it is worth highlighting that cutaneous infections caused by environmental microbacteria are some of the most serious, albeit rare, as long as basic asepsis principles are applied.

After a mesotherapy session, spending time in damp places, direct sun exposure, or exposure to extreme temperatures is not advisable. Avoid: saunas, gyms, beach, swimming pools, tight clothing, waxing…

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There are four different injection techniques in mesotherapy: point by point, coating, epidermal mesotherapy, intradermal papule.

Choosing one technique over the other depends on:

  • Pathology to be treated
  • Objectives
  • Evolutionary state of the pathology itself
  • Professional expertise

When it comes to preventing side effects (mainly infections), it is important to define a skin asepsis protocol (Chlorhexidine, benalkonium chloride, triclosan) before, after, and during the treatment as a way to protect the treated skin (using semi-occlusive films that are applied as a spray, creating a protective semipermeable film) and basic recommendations that the patient must follow.

In the case of cellulite, after the injections, it is advisable to perform a manual lymphatic drainage massage to move the fat and thus dissolve it faster. At the end of each session it is important to drink plenty of water so that the body releases the toxins that are released with the treatment.

Number of sessions needed

It obviously depends on the pathology to be treated. In the particular case of cellulite, 6 sessions are usually necessary at monthly intervals, followed by 10 sessions at 15-day intervals. It is recommended to have maintenance sessions (1 monthly session every year).


Mesotherapy Treatment in Valencia

Dr. Gabriel Serrano Sanmiguel


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